The primary purpose of this work was to develop a controlled-release dosage form using a cellulose-based hydrogel cross-linked with propylene glycol. Hydrogels were created by crosslinking the polymer Chitosan HCl+ Na CMC with propylene glycol, an appropriate crosslinking agent. The cross linking technique provided the hydrogel with good swelling as well as controlled release qualities. The influence of calcium chloride level on drug content and 75% CDR was determined to be insignificant. However, the effect of Calcium Chloride concentration on swelling index was significant, indicating that as the Calcium Chloride concentration increased, the swelling index of the hydrogel dropped. Again, response time had a significant influence on drug content and t75 percent CDR, meaning that as reaction time grew, so did drug content and t75 percent CDR of the hydrogel. However, the impact of response time on the swelling index was not statistically significant. The drug content, swelling index and t75 percent CDR of run BB1 are the best when compared to all replies. The drug content, swelling index and time to 75 percent CDR for this run are 99.5 percent, 276.64 percent and 3.5 hours, respectively. So BB1 was utilized to evaluate the revised formulation and it achieved the highest in-vitro release of 94.24 percent in 6 hours. Different kinetic models were fitted to the in-vitro data and the best model was Higuchi with a non-fickian manner of drug release. Stability data revealed that the formulations were stable during the course of the research. The study revealed that the manufactured hydrogel can give a prolonged release effect with higher bioavailability, which will undoubtedly improve its absorption throughout the body.
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